Title:
【発明の名称】新規フェニルエタノールアミン類
Document Type and Number:
Japanese Patent JPH03503405
Kind Code:
A
Abstract:
PCT No. PCT/EP88/01083 Sec. 371 Date Aug. 20, 1990 Sec. 102(e) Date Aug. 20, 1990 PCT Filed Nov. 29, 1988 PCT Pub. No. WO90/06299 PCT Pub. Date Jun. 14, 1990.The invention relates to new phenylethanolamines of general formula (I) wherein A represents a straight-chained or branched alkylene group, B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group, R1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group, R2 represents a hydrogen atom or an amino group, R3 represents a cyano group, a hydrogen, chlorine or bromine atom and R4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group, the optical isomers and diastereoisomers and acid addition salts thereof. The new compounds of formula I, the optical isomers and diastereoisomers and acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof with inorganic or organic acids, have valuable pharmacological properties, namely an effect on the metabolism, preferably the effect of lowering blood sugar and reducing body fat and they may also be used as performance enhancers in animals. The new compounds of general formula I above may be prepared by methods known per se.
Inventors:
Furnaus Rudolph
Reifenman Fret
Sauter Robert
Grell Wolfgang
Rupprecht Eckhart
Reifenman Fret
Sauter Robert
Grell Wolfgang
Rupprecht Eckhart
Application Number:
JP50005189A
Publication Date:
August 01, 1991
Filing Date:
November 29, 1988
Export Citation:
Assignee:
Boehringer Ingelheim Fethmedika Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/13; A61K31/135; A61K31/16; A61K31/19; A61K31/195; A61K31/215; A61K31/22; A61K31/275; A61K31/40; A61P3/00; A61P43/00; C07C213/00; C07C215/30; C07C215/32; C07C215/48; C07C215/54; C07C215/68; C07C217/56; C07C217/62; C07C221/00; C07C225/16; C07C227/00; C07C229/38; C07C233/43; C07C237/30; C07C253/30; C07C255/53; C07C255/59; (IPC1-7): A61K31/13; A61K31/16; A61K31/19; A61K31/215; A61K31/275; C07C213/00; C07C215/30; C07C215/32; C07C215/48; C07C215/68; C07C217/56; C07C221/00; C07C225/16; C07C227/00; C07C229/38; C07C233/43; C07C237/30; C07C253/30; C07C255/59
Attorney, Agent or Firm:
Minoru Nakamura (8 outside)