Title:
【発明の名称】新規タキソイド類、その製造およびそれらを含む製薬学的組成物
Document Type and Number:
Japanese Patent JPH10500979
Kind Code:
A
Abstract:
New taxoids having general formula (I), (II) preparation thereof and pharmaceutical compositions containing them. In general formula (I): Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy, and Rb is hydrogen or Ra and Rb form together with the carbon atom to which they are linked a ketone function, Z is a hydrogen atom or a radical having general formula (II) wherein R1 is an optionally substituted benzoyl radical, a thenyl or furoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphtyl or heterocyclic aromatic radical, and R4 and R5, similar or different, represent an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, aryl or heterocyclyl radical, with the condition that R5 does not represent a methyl radical. The new products having general formula (I) wherein Z is a radical having general formula (II) have remarkable antitumoral and antileukaemic properties.
More Like This:
Inventors:
Bouchard, Elbe
Burza, Jiyan-Dominique
Commerson, Alan
Collier, Terrier
Zukko, Maruteinu
Burza, Jiyan-Dominique
Commerson, Alan
Collier, Terrier
Zukko, Maruteinu
Application Number:
JP50045996A
Publication Date:
January 27, 1998
Filing Date:
June 07, 1995
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
A61K31/335; A61K31/337; A61P35/00; C07D305/14; (IPC1-7): C07D305/14; A61K31/335
Attorney, Agent or Firm:
Heiyoshi Odashima