Title:
【発明の名称】非ペプチド系レニン阻害剤
Document Type and Number:
Japanese Patent JPH04505608
Kind Code:
A
Abstract:
A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.
Inventors:
Huang, Anthony K. El
Baker, William Earl
Armiger, York-Lin
Rosenberg, Saul H
De, Biswanus
Platztoner, Jakob Jei
Boyd, Stephen A
Kenf, Dale Jei
Siam, Hin Li Yun
Cleat, Hollis Day
Robert A, Mantay
Baker, William Earl
Armiger, York-Lin
Rosenberg, Saul H
De, Biswanus
Platztoner, Jakob Jei
Boyd, Stephen A
Kenf, Dale Jei
Siam, Hin Li Yun
Cleat, Hollis Day
Robert A, Mantay
Application Number:
JP51091589A
Publication Date:
October 01, 1992
Filing Date:
October 03, 1989
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/19; A61K31/265; A61K31/415; A61K31/4166; A61K31/445; A61K31/4465; A61K31/66; A61P9/00; A61P9/12; A61P43/00; C07C237/08; C07C237/22; C07C317/28; A61K31/16; C07C323/57; C07C323/58; C07D203/18; C07D211/44; C07D211/46; C07D211/62; C07D211/96; C07D233/36; C07D233/54; C07D233/56; C07D263/22; C07D295/185; C07D401/12; C07D407/12; C07D413/12; C07D521/00; (IPC1-7): A61K31/16; A61K31/19; A61K31/265; A61K31/415; A61K31/445; A61K31/66; C07C237/22; C07C323/57; C07D211/46; C07D211/62; C07D233/36; C07D263/22; C07D521/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)