Title:
【発明の名称】新規な置換フェノキシイソ酪酸およびエステル
Document Type and Number:
Japanese Patent JP2885639
Kind Code:
B2
Abstract:
The substituted phenoxyisobutyric acids and their esters of formula I: in which: - X represents an oxygen atom, a sulphur atom or a single bond; - A represents a single bond or a hydrocarbon radical containing from 1 to 9 carbon atoms in a straight or branched chain optionally containing a double bond, a cyclopropyl radical, an oxygen atom or a carbonyl radical, or optionally substituted by a halogen atom or a hydroxyl radical; - R represents a hydrogen atom or an alkyl radical containing from 1 to 6 carbon atoms in a straight or branched chain optionally substituted by one or two hydroxyl radicals; - R1 and R3: . each simultaneously represent a hydrogen atom, or . together form a bridge (CH2)n in which n takes the values 1 or 2, or . R1 represents: . a methyl radical, or . a single bond which forms a double bond with the group A when the latter is a hydrocarbon radical, and . in each of these cases, R3 simultaneously represents a hydrogen atom; - R2 and R6, which are identical or different, each represent a hydrogen atom or a methyl radical; - R4 and R5, which are identical or different, each represent an alkyl radical containing from 1 to 6 carbon atoms in a straight or branched chain; - R7 represents a hydrogen atom or a labile protective group such as, for example, a CH3CO-, C2H5O-CH2- or benzyl radical; and - Z represents a hydrogen or halogen atom or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms in a straight or branched chain; and, when they exist, the corresponding enantiomers and diastereoisomers, as well as the physiologically tolerable salts of the compounds I with appropriate bases, can be used in therapeutics.d
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Inventors:
JIRUBEERU RUGUNIE
KUROODO GYUIRONO
JAN HOORU UIREN
ARUBEERU RUNAARU
KURISUCHIN BURUNYO
KUROODO GYUIRONO
JAN HOORU UIREN
ARUBEERU RUNAARU
KURISUCHIN BURUNYO
Application Number:
JP8186994A
Publication Date:
April 26, 1999
Filing Date:
April 20, 1994
Export Citation:
Assignee:
ADEIIRU
International Classes:
A61K31/19; A61K31/215; A61K31/35; A61K31/352; A61P3/06; A61P3/08; A61P3/10; A61P9/10; C07C51/09; C07C59/68; C07C59/90; C07C67/343; C07C69/712; C07C69/734; C07C51/367; C07C319/14; C07C319/20; C07C323/20; C07C323/22; C07D311/72; (IPC1-7): C07C59/68; A61K31/19; A61K31/215; A61K31/35; C07C51/09; C07C59/90; C07C67/343; C07C69/734; C07C319/14; C07C319/20; C07C323/20; C07C323/22; C07D311/72
Domestic Patent References:
| JP525115A | ||||
| JP48813B1 | ||||
| JP4939995B1 |
Attorney, Agent or Firm:
Hajime Tsukuni (2 outside)