Title:
【発明の名称】新規ビタミンD類似体
Document Type and Number:
Japanese Patent JP3246913
Kind Code:
B2
Abstract:
PCT No. PCT/DK91/00091 Sec. 371 Date Jul. 23, 1992 Sec. 102(e) Date Jul. 23, 1992 PCT Filed Mar. 22, 1991 PCT Pub. No. WO91/15475 PCT Pub. Date Oct. 17, 1991.The invention relates to compounds of formula I I in which formula X is hydrogen or hydroxy; Y is oxygen, sulphur, or oxidized sulfur (S(O) or S(O2)); R1 and R2, which may be the same or different, stand for hydrogen or C1-C6 hydrocarbyl, or R1 and R2, taken together with the carbon atom (starred in formula I) bearing the group X, form a C3-C8 carbocyclic ring; Q is a C1-C8 hydrocarbylene diradical. R3 is hydrogen or C1-C6 hydrocarbyl. R1, R2 and/or Q, may be optionally substituted with one or more deuterium or fluorine atoms; n is 0 or 1. The present compounds show antiinflammatory and immunomodulating effects as well as a strong activity in inducing cell differentiation and inhibiting undesirable proliferation of certain cancer and skin cells.
Inventors:
Calvary, Martin John
Glue Suansen, Gunnar
Binerup, Ehant Thondahl
Glue Suansen, Gunnar
Binerup, Ehant Thondahl
Application Number:
JP50676491A
Publication Date:
January 15, 2002
Filing Date:
March 22, 1991
Export Citation:
Assignee:
LEO PHARMACEUTICAL PRODUCTS LIMITED ACTISELSCAB (LEVENS CHEMISKE FABRIC PRODUCTIONS ACTISELSCAB)
International Classes:
A61P3/08; A61P9/12; A61P11/00; A61K31/59; A61P17/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07C401/00; (IPC1-7): C07C401/00
Domestic Patent References:
| JP58126861A | ||||
| JP58126862A | ||||
| JP2163A |
Other References:
【文献】欧州特許出願公開377743(EP,A1)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)