Title:
【発明の名称】核酸が媒介する電子伝達
Document Type and Number:
Japanese Patent JPH09506510
Kind Code:
A
Abstract:
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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Inventors:
Mead, thomas jay
Kaiem, John F.
Fraser, Scott E.
Kaiem, John F.
Fraser, Scott E.
Application Number:
JP51624994A
Publication Date:
June 30, 1997
Filing Date:
December 05, 1994
Export Citation:
Assignee:
California Institute of Technology
International Classes:
C07H21/00; C07H23/00; C12Q1/68; C12Q1/6818; C12N15/09; C12Q1/6825; C12Q1/6827; G01N33/566; (IPC1-7): C12N15/09; C07H21/00; C12Q1/68; G01N33/566
Attorney, Agent or Firm:
Takashi Ishida (3 others)