Title:
【発明の名称】オリゴマー類、それらの使用および製剤
Document Type and Number:
Japanese Patent JP3187455
Kind Code:
B2
Abstract:
A water-soluble, rigid backbone oligomer is claimed which has a mol.wt. less than 10,000 and comprises recurring units coupled by carbonyl linking moieties, the oligomer having anionic gps. and predominantly linear geometry such that regular spacing between anionic gps. exists in an aqs. medium. The oligomer may be (A) a polyurea of formula (I) R-(NH-CO)m-(NH-X-NH-CO)n-NH-R3. (R = H, 1-4C alkyl, phenyl or phenyl substd. with 1-2 R' gps. and up to 3 substits. selected from Cl, Br or 1-4C alkyl; R1 = SO3R2, CO2R2, PO3(R2)2 or OPO3R2; R2 = H or a cation; m = 0 or 1, provided that when m = 0 R = H; X = a gp. (i)-(xii) where Y = CO2, -C-C-; -N=N-, -CO-NH-, -N(O)=N- or -CR=N-N=CR-; n = 3-50; R3 = R or XNH2. (B) a polycarbonate of formula (II) X1-O-(CO-O-X-O)-nX2 (II) (X1 = HO-X, 1-4C alkyl, phenyl, phenyl substd. with 1-2 R1 and up to 3 substits. selected from Cl, Br and 1-4C alkyl; X2 = H or CO2X1). (C) a polyester of formula (III) R4O-(CO-X3-CO-O-X-O)-nR5 (III) (R4 = as for R2 or X1; R5 = R41O-CO-X3-CO-; R41 = as for R4 or R2; X3 = a gp. of formula (viii) or (xiii)-(xxii), or (D) a polyamide of formula (IV) R6-(CO-X3-CO-NH-X-NH)n-R7 (IV). (where R6 = H2N-X-NH, R2O, RNH or R-CO-NH-X-NH-; R7 = H, R2O-CO-X3-CO-, R-CO- or RNH-CO-X3-CO-).
Inventors:
Alan D. Cardin
Richard El. Jackson
Michael Jay Mullins
Richard El. Jackson
Michael Jay Mullins
Application Number:
JP16812691A
Publication Date:
July 11, 2001
Filing Date:
July 09, 1991
Export Citation:
Assignee:
The Dow Chemical Company
Merrell Dow Pharmaceuticals Inc.
Merrell Dow Pharmaceuticals Inc.
International Classes:
A61K31/185; A61K31/74; A61K31/765; A61K31/785; A61K31/795; A61K49/00; C07C309/60; A61P31/12; A61P31/18; C07C303/32; C07C309/32; C07C309/42; C07C309/51; C08G18/00; C08G18/32; C08G18/76; C08G63/02; C08G63/06; C08G63/18; C08G63/19; C08G63/688; C08G63/692; C08G64/00; C08G64/04; C08G64/06; C08G64/08; C08G64/12; C08G69/00; C08G69/26; C08G69/32; C08G71/02; C08L67/00; C08L67/02; C08L69/00; A61K; C08G; (IPC1-7): C08G18/32; A61K31/765; C07C309/42; C08G63/19; C08G64/04; C08G69/32
Other References:
【文献】英国特許781479(GB,B)
Attorney, Agent or Firm:
Aoki Akira (4 outside)