Title:
MEDICINE CONSISTING OF AZAMITHOSENES
Document Type and Number:
Japanese Patent JPH0616551
Kind Code:
A
Abstract:
PURPOSE: To obtain a medicine contg. azamitosene and iminoazamitosene and having remarkable activity against neoplastic diseases. CONSTITUTION: This medicine consists of an antitumorigenic amt. of compds. selected from among compds. represented by formula I (where each of R and Z is a group represented by formula II), e.g. azamitosene such as 6-(N- aziridinyl)-7-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-5,8-dio ne-3-acetate and compds. represented by formula III (where Z is H or a group represented by formula IV), e.g. ininoazamitosene such as syn/anit-6-acetamido-5-imino-7- methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-8-one and a medicinally allowavle carrier. This medicine has remarkable activity against neoplastic diseases such as ovarian cancer, large bowel cancer and myeloma.
Inventors:
EDOWAADO BII SUKIBO
IMADARU ISURAMU
DEBITSUDO ESU ARUBAATO
IMADARU ISURAMU
DEBITSUDO ESU ARUBAATO
Application Number:
JP13238491A
Publication Date:
January 25, 1994
Filing Date:
March 26, 1991
Export Citation:
Assignee:
UNIV ARIZONA
International Classes:
A61K31/415; A61P35/00; C07D487/04; (IPC1-7): A61K31/415
Attorney, Agent or Firm:
Nao Kuwahara
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