Title:
【発明の名称】オルニチン・デカルボキシラーゼ阻害性環式アミノオキシ化合物
Document Type and Number:
Japanese Patent JPH07508045
Kind Code:
A
Abstract:
PCT No. PCT/EP94/01035 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 2, 1994 PCT Pub. No. WO94/24093 PCT Pub. Date Oct. 27, 1994.Compounds of formula (I): H2N-(CH2)n-A-(CH2)m-O-NH2 and salts thereof are described in which the radical A is C3-C6 cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H2N-O- and the amino group -NH2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H2N-(CH2)n- and -(CH2)m-O-NH2 are not bonded to the same ring carbon of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.
Inventors:
Fry, jerk
Stanek, Yaroslav
Stanek, Yaroslav
Application Number:
JP52268994A
Publication Date:
September 07, 1995
Filing Date:
April 02, 1994
Export Citation:
Assignee:
Novartis Akchen Gezel Shaft
International Classes:
A61P33/02; A61P35/00; A61K31/13; A61P43/00; C07C239/08; C07C239/20; (IPC1-7): C07C239/08; A61K31/13
Attorney, Agent or Firm:
Takashi Ishida (3 others)