Title:
【発明の名称】PARPインヒビター、当該インヒビターを含む薬学的組成物および当該インヒビターの使用方法
Document Type and Number:
Japanese Patent JP2002515072
Kind Code:
A
Abstract:
The present invention relates to PARP inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat tissue damage resulting from cell damage or death due to necrosis or apoptosis, effect neuronal activities not mediated by NMDA toxicity; to treat neural tissue damage resulting from ischemia and reperfusion injury, neurological disorders and neurodegenerative diseases; to prevent or treat vascular stroke; to treat or prevent cardiovascular disorders; to treat other conditions and/or disorders such as age-related macular degeneration, AIDS and other immune senescence diseases, arthritis, atherosclerosis, cachexia, cancer, degenerative diseases of skeletal muscle involving replicative senescence, diabetes, head trauma, immune senescence, inflammatory bowel disorders (such as colitis and Crohn's disease), muscular dystrophy, osteoarthritis, osteoporosis, chronic and/or acute pain (such as neuropathic pain), renal failure, retinal ischemia, septic shock (such as endotoxic shock), organ damage due to transplantation, and skin aging; to extend the lifespan and proliferative capacity of cells; to alter gene expression of senescent cells; or to radiosensitize hypoxic tumor cells.
Inventors:
Paul F Jackson
Ja-hee Lee
Keith M. McLin
Gee Chan
Ja-hee Lee
Keith M. McLin
Gee Chan
Application Number:
JP51697199A
Publication Date:
May 21, 2002
Filing Date:
September 02, 1998
Export Citation:
Assignee:
Guildford Pharmaceuticals Incorporated
International Classes:
C07D243/14; A61K31/00; A61K31/192; A61K31/4365; A61K31/472; A61K31/473; A61K31/50; A61K31/501; A61K31/5025; A61K45/00; A61P1/00; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P17/00; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P43/00; C07D209/56; C07D217/24; C07D221/12; C07D221/14; C07D221/18; C07D237/26; C07D491/06; C07D495/04; C07D495/06; C07G99/00; (IPC1-7): A61K45/00; A61K31/192; A61K31/4365; A61K31/472; A61K31/473; A61K31/501; A61K31/5025; A61P1/00; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P17/00; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P43/00; C07D209/56; C07D217/24; C07D221/12; C07D221/14; C07D221/18; C07D237/26; C07D243/14; C07D491/06; C07D495/04; C07D495/06
Attorney, Agent or Firm:
Masatake Shiga (8 outside)