Title:
【発明の名称】副甲状腺ホルモンのレセプターとそれをコードしているDNA
Document Type and Number:
Japanese Patent JP3464796
Kind Code:
B2
Abstract:
An antagonist or agonist compound for use in the treatment of hypercalcemia or hypocalcemia. The compound is identifiable as being a compound capable of competing with a parathyroid hormone or parathyroid hormone-related protein for binding to a parathyroid hormone receptor. Identification is carried out by contacting a polypeptide with a parathyroid hormone or parathyroid hormone-related protein in the presence or absence of a candidate compound. The polypeptide comprises at least six amino acids and less than the complete amino acid sequence of a parathyroid hormone receptor having an amino acid sequence with at least 30% identity to the amino acid sequence shown in SEQ. ID NO. 3.
Inventors:
Segre Guinobu
Kronenberg Henry M
Abou Samla Abdul Buddy
Japner Harald
Potts Joan Tay Junior
Sipani Arnestina
Kronenberg Henry M
Abou Samla Abdul Buddy
Japner Harald
Potts Joan Tay Junior
Sipani Arnestina
Application Number:
JP51003592A
Publication Date:
November 10, 2003
Filing Date:
April 06, 1992
Export Citation:
Assignee:
THE GENERAL HOSPITAL CORPORATION
International Classes:
A61K38/00; A61K39/00; A61K39/395; A61P3/00; A61P3/02; A61P3/14; A61P5/12; C07K5/00; C07K7/06; C07K7/08; C07K14/435; C07K14/635; C07K14/705; C07K14/72; A01K67/027; C07K16/00; C07K16/28; C12N1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/113; C12N15/12; C12N15/85; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/68; G01N33/78; G01N33/84; C12R1/91; (IPC1-7): C12N15/09; A01K67/027; A61K38/00; A61K39/395; A61P3/14; C07K7/08; C07K14/705; C07K16/28; C12N5/10; C12P21/02; C12Q1/68; G01N33/15; G01N33/566
Domestic Patent References:
| JP6413100A |
Other References:
【文献】TWENTY-SEVENTH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY,Vol.105,No.4,Pt.2(1987)p15a-72
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)