Title:
【発明の名称】抗血小板剤としての立体配位が制限されたペプチド類似体
Document Type and Number:
Japanese Patent JP3398747
Kind Code:
B2
Abstract:
The present invention relates to cyclic peptide analogs containing a pseudo-bond, useful as platelet aggregation inhibitors. An example of a compound of this invention includes Cyclo[Ala PSI [CH2NH]-Arg-Gly-Asp- delta -Glu](NHBn).CF3CO2H. These compounds inhibit the binding of fibrinogen to the platelet GPIIb-IIIa integrin receptor which inhibits platelet aggregation and therefore these compounds act as potent antithrombotics.
Inventors:
Harbeson, Scott Elle.
Bitonty. Alan Jay.
Bitonty. Alan Jay.
Application Number:
JP50059594A
Publication Date:
April 21, 2003
Filing Date:
May 14, 1993
Export Citation:
Assignee:
Merrell Dow Pharmaceuticals Inc.
International Classes:
A61P7/02; C07K5/02; C07K5/06; C07K5/08; C07K5/083; C07K5/093; A61K38/00; C07K5/10; C07K5/103; C07K5/113; C07K7/02; C07K7/06; C07K7/56; C07K14/75; (IPC1-7): C07K5/06; A61K38/00; A61P7/02; C07K5/08; C07K5/10; C07K7/02
Attorney, Agent or Firm:
Katsuro Sasai