Title:
【発明の名称】カテプシンDならびにプラスメプシン▲I▼および▲II▼のペプチド模倣インヒビター
Document Type and Number:
Japanese Patent JPH11508604
Kind Code:
A
Abstract:
The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria.
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Inventors:
Magel, Pavel
Collins, Jack
Gurnik, surge
Ericson, John
Bread, wenkushi
Essence Tat, Michael Allen
Collins, Jack
Gurnik, surge
Ericson, John
Bread, wenkushi
Essence Tat, Michael Allen
Application Number:
JP52960997A
Publication Date:
July 27, 1999
Filing Date:
February 20, 1997
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
C07D317/60; A61K31/165; A61K31/195; A61K31/215; A61K31/357; A61K31/36; A61K31/44; A61K38/00; A61P25/28; A61P33/02; A61P35/00; C07C229/36; C07D213/30; C07D255/02; C07K5/02; C07K5/027; C07K7/02; C07K7/56; C07K14/81; (IPC1-7): C07C229/36; A61K31/165; A61K31/195; A61K31/215; A61K31/36; A61K31/44; A61K38/00; C07D213/30; C07D255/02; C07D317/60; C07K5/027; C07K14/81
Attorney, Agent or Firm:
Shusaku Yamamoto