Title:
【発明の名称】耐性の誘導に有用なペプチド
Document Type and Number:
Japanese Patent JPH07505365
Kind Code:
A
Abstract:
The present invention is based on the discovery that subcutaneous administration of a peptide comprising at least one T cell epitope of a protein allergen or other protein antigen results in T cell tolerance upon subsequent exposure to the allergen or other antigen. Peptides useful for inducing tolerance in a mammal, such as a human by subcutaneous administration or other routes of administration are within the scope of this invention. Such peptides include peptide X (SEQ ID NO: 7), peptide Y (SEQ ID NO: 8), peptide Z (SEQ ID NO: 9), peptide A (SEQ ID NO: 10), peptide B (SEQ ID NO: 11), peptide C (SEQ ID NO: 12), peptide D (SEQ ID NO: 13), and peptide E (SEQ ID NO: 14), each as shown in the figure. It is preferred that such peptides be administered in soluble form.
Inventors:
Geoffer, Malcolm El
Garman, Lichyard Day
Green Stain, The Julia El
Kuo, May-Chi Young
Breiner, Thomas J.A.
Mobil, malcolm
Garman, Lichyard Day
Green Stain, The Julia El
Kuo, May-Chi Young
Breiner, Thomas J.A.
Mobil, malcolm
Application Number:
JP51671593A
Publication Date:
June 15, 1995
Filing Date:
March 25, 1993
Export Citation:
Assignee:
Imyulogic Pharmaceutical Co., Ltd.
International Classes:
A61K39/00; A61K39/35; A61P37/08; C07K7/08; C07K14/47; C07K16/18; C12N15/09; C12N15/12; C12N15/62; C12P21/02; G01N33/50; A61K38/00; (IPC1-7): A61K39/35; A61K39/00; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Heiyoshi Odashima