Title:
【発明の名称】ホスホリルフルオログルコサミン誘導体
Document Type and Number:
Japanese Patent JP2980693
Kind Code:
B2
Abstract:
NEW MATERIAL:A compound expressed by the formula (either of R<1> and R<4> is OH or protected OH and the other is F; R<2> and R<3> are 6-20C aliphatic acyl which may be substituted with a group selected from halogen, aryl, aralkyl, OH and 6-10C aliphatic acyloxy) and salts thereof. EXAMPLE:1,2-Dideoxy-1-fluoro-2-[(R)-3'-hydroxydecanoylamino]-3-O-[(R)- tetradecanoyloxytetradecanoyl]-alpha-D-glucopyranosyl-4-phosphate. USE:Having excellent macrophage activating action and useful as immunopotentiators or antitumor agents. PREPARATION:For example, glucosamine as a starting raw material is passed through 13 steps to afford the objective compound expressed by the formula (R<1> is F; R<4> is OH).
Inventors:
SHIOSAKI MASAO
ISHIDA NOBORU
ARAI MASAMI
HIRAOKA TETSUO
KOBAYASHI TOMOO
AKAMATSU MINORU
NISHIJIMA MASAHIRO
ISHIDA NOBORU
ARAI MASAMI
HIRAOKA TETSUO
KOBAYASHI TOMOO
AKAMATSU MINORU
NISHIJIMA MASAHIRO
Application Number:
JP40108790A
Publication Date:
November 22, 1999
Filing Date:
December 10, 1990
Export Citation:
Assignee:
SANKYO KK
International Classes:
C07H5/06; A61K31/00; A61K31/70; A61K31/7024; A61P35/00; A61P37/00; A61P37/04; C07H11/04; C07H13/06; C07H13/12; C07H15/02; C07H15/10; C07H15/18; (IPC1-7): C07H13/06
Domestic Patent References:
| JP62108895A |
Attorney, Agent or Firm:
Akio Ohno (2 outside)