Title:
【発明の名称】金属アルコキシドとβ-ラクタムを使用する置換イソセリンエステルの製造
Document Type and Number:
Japanese Patent JP3469237
Kind Code:
B2
Abstract:
Prepn. of a substd. isoserine ester (I) comprises reacting a beta-lactam of (II) with a metal alkoxide MOCE1E2E3 (III). In the formulae, R1 = OR6, SR7, or NR8R9; R2 = H, 1-15C alkyl, 2-15C alkenyl, 2-15C alkynyl, 6-15C aryl, or heteroaryl (all opt. substd.); R3, R4 = as R2, or acyl, provided that R3 and R4 are not both acyl; R5 = COR10, COOR10, COSR10, CONR8R10, SO2R11, or POR12R13; R6 = as R2, OH protecting gp., or gp. to increase water solubility in a taxane deriv.; R7 = as R2 (but not H), or SH protecting gp.; R8 = as R2; R9 = amino protecting gp.; R10 = as R2 (but not H); R11-R13 = as R2 (but not H), OR10 or NR8R14; R14 = as R2; and E1-E3 = H, hydrocarbon, or cyclic; provided that at least one of E1-E3 is other than H. Prepn. of a taxane deriv. comprises the above process, in which one of E1-E3 = H and CE1E2E3 = a polycyclic skeleton, to form an intermediate; and converting this into the taxane deriv.
Inventors:
Houlton, Robert A.
Application Number:
JP50629993A
Publication Date:
November 25, 2003
Filing Date:
September 22, 1992
Export Citation:
Assignee:
Florida State University
International Classes:
C07D205/08; C07C227/22; C07C229/22; C07C229/26; C07C229/34; C07C231/12; C07C233/87; C07D305/14; C07D317/60; C07D403/00; C07D407/12; C07D409/12; C07F7/00; C07F7/08; C07F7/18; C07F9/568; (IPC1-7): C07D305/14; C07D317/60; C07D407/12; C07D409/12
Domestic Patent References:
| JP386860A | ||||
| JP61782A |
Other References:
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Ｔｅｔｒａｈｅｄｒｏｎ，（２１ Ａｕｇｕｓｔ １９９２），Ｖｏｌ．４８，Ｎｏ．３４，ｐ．６９８５−７０１２
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)