Title:
【発明の名称】プロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2002515411
Kind Code:
A
Abstract:
The present invention provides bis-aminomethyl carbonyl protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
Inventors:
William Edward Bondinel
Rene Louise Death Jar Race
Daniel Frank Baber
Dennis Shinji Yamashita
Rene Louise Death Jar Race
Daniel Frank Baber
Dennis Shinji Yamashita
Application Number:
JP2000549192A
Publication Date:
May 28, 2002
Filing Date:
May 20, 1999
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D295/08; A61K31/166; A61K31/4402; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/497; A61K31/506; A61K31/519; A61K31/53; A61K31/5375; A61K31/5377; A61K38/00; A61P1/02; A61P3/14; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P35/04; A61P43/00; C07C271/22; C07C311/16; C07D213/56; C07D213/71; C07D213/89; C07D215/48; C07D215/54; C07D295/155; C07D307/84; C07D307/85; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D487/04; C07D495/04; C07K5/06; C07K5/078; (IPC1-7): C07C271/22; A61K31/166; A61K31/4402; A61K31/4409; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/497; A61K31/506; A61K31/519; A61K31/53; A61K31/5377; A61K38/00; A61P1/02; A61P3/14; A61P19/02; A61P19/10; A61P29/00; A61P35/04; A61P43/00; C07C311/16; C07D213/56; C07D213/71; C07D215/48; C07D295/08; C07D307/84; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14; C07D487/04; C07D495/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)