Title:
【発明の名称】保護ペプチド抗原
Document Type and Number:
Japanese Patent JPS60500215
Kind Code:
A
Abstract:
A peptide has been isolated and made comprising an epitope of a circumsporozoite protein of a member of the genus Plasmodium. The peptide is useful in development of a vaccine against malaria and it can be prepared by recombinant DNA techniques in the form of a fusion protein. DNA fragments have been produced coding for such peptide and microorganisms have been transformed expressing said peptide. An immunodominant region has been identified within such a peptide and a shorter peptide analog has been prepared, the analog displaying immunoreactivity with a monoclonal antibody to the peptide substantially equivalent to that of the peptide itself.
Inventors:
Colman, David Earl
Ellis, Jojoan
Gottdson, Siegel
Nutsentzbaig, Ruth S
Nutsentzvig, Victor N
Schlezinger, David Etsch
Suvetsk, Pamela S
Zabara, Huidel
Ellis, Jojoan
Gottdson, Siegel
Nutsentzbaig, Ruth S
Nutsentzvig, Victor N
Schlezinger, David Etsch
Suvetsk, Pamela S
Zabara, Huidel
Application Number:
JP50099484A
Publication Date:
February 21, 1985
Filing Date:
January 27, 1984
Export Citation:
Assignee:
New York University
International Classes:
C12N15/00; A61K39/00; A61K39/002; A61K39/015; C07G99/00; C07H21/04; C07K7/06; C07K7/08; C07K14/435; C07K14/44; C07K14/445; C07K19/00; C12N1/00; C12N1/20; C12N15/02; C12N15/30; C12P19/34; C12P21/00; C12P21/02; C12R1/19; (IPC1-7): C07K15/06; A61K39/002; C07K7/06; C07K7/08; C12N1/00; C12N15/00
Other References:
PROC.NATL.ACAD.SCI.USA=1982
AM.J.TROP.MED.HYG=1980
AM.J.TROP.MED.HYG=1980
Attorney, Agent or Firm:
Masatake Shiga