Title:
【発明の名称】タンパク性の脂質含有粒子
Document Type and Number:
Japanese Patent JPH06506826
Kind Code:
A
Abstract:
Proteinaceous, lipid-containing particles can be prepared by co-expressing in a host cell (i) a self-assembling protein moiety in circumstances where the protein assembles to form a core, which then buds off from the host cell, thereby acquiring a lipid envelope derived from the host cell membrane and (ii) a membrane-bound protein moiety, which becomes integrated in the lipid envelope. The particles have a wide variety of uses. They may be used as an antigen presentation system, or they may for example have site-specific targeting ability, fusogenic properties, enzymic activity, cytotoxic activity, diagnostic utility and/or pharmaceutical activity.
Inventors:
Adams, Sally Elizabeth
Niger Robert Burns
French, Timothy
Girling, Andrew John Hubbert
Kingsman, Alan John
Kingsman, Susan Mary
Niger Robert Burns
French, Timothy
Girling, Andrew John Hubbert
Kingsman, Alan John
Kingsman, Susan Mary
Application Number:
JP50771592A
Publication Date:
August 04, 1994
Filing Date:
April 10, 1992
Export Citation:
Assignee:
British Bio-Technology Limited
International Classes:
A61K39/12; A61K39/155; A61K39/205; A61K39/21; A61P31/12; C07K14/00; C07K14/005; C07K14/11; C07K14/145; C07K14/155; C07K14/16; C07K14/195; C07K14/52; C07K14/705; C07K16/00; C07K19/00; C12N5/10; C12N7/04; C12N15/09; C12N15/12; C12N15/41; C12N15/47; C12N15/49; C12N15/87; C12P21/02; G01N33/53; G01N33/569; A61K38/00; A61K39/00; (IPC1-7): C12P21/02; A61K39/12; C07K15/04; C07K15/16; C12N5/10; C12N15/48; C12N15/86; G01N33/53; G01N33/569
Attorney, Agent or Firm:
Shintaro Nogawa