Title:
【発明の名称】ハイブリッド化合物の精製
Document Type and Number:
Japanese Patent JPH05505191
Kind Code:
A
Abstract:
A method for purifying from a mixture of hybrid compound which contains a portion of IL-2, which portion includes at least a region of the IL-2R binding domain of IL-2, which region is effective to cause the hybrid compound to bind to cells containing an IL-2R. The method includes passing the mixture containing the hybrid compound over a column having attached thereto molecules consisting of or containing a complex sugar moiety with affinity for the hybrid compound, and eluting the hybrid compound with a suitable eluant. The invention also features related complexes of the hybrid compound and assays for the hybrid compound.
Inventors:
Estis, Leonard F
Application Number:
JP50606891A
Publication Date:
August 05, 1993
Filing Date:
February 26, 1991
Export Citation:
Assignee:
Seragen Incorporated
International Classes:
A61P37/06; C07K1/16; C07K1/22; C07K14/00; C07K14/195; A61K38/00; C07K14/52; C07K14/54; C07K14/55; C07K14/76; C07K19/00; G01N30/88; G01N33/68; (IPC1-7): A61K37/02; C07K3/20; C07K15/12; G01N30/88; G01N33/68
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)