Title:
【発明の名称】親水性基に対する共有結合を容易ならしめるためのポリペプチド類の部位特異的均一修飾
Document Type and Number:
Japanese Patent JPH02502646
Kind Code:
A
Abstract:
A homogeneously modified protein is provided having one or more selected naturally occurring lysine residues replaced by a suitable amino acid, or having one or more lysine residues substituted for other amino acids or inserted into a polypeptide sequence, leaving selected lysine residues having epsilon -amino groups in the protein and coupling amine reactive compounds to selected lysine residues. Methods for producing the selected homogeneously modified proteins and pharmaceutical compositions containing such proteins are provided.
Inventors:
Shaw, Gray
Application Number:
JP50092589A
Publication Date:
August 23, 1990
Filing Date:
December 22, 1988
Export Citation:
Assignee:
Genetics Institute, Inc.
International Classes:
C12N15/09; A61K38/00; A61K47/48; C07K1/113; C07K14/505; C07K14/52; C07K14/53; C07K14/535; C07K14/54; C07K14/545; C07K14/55; C07K14/575; C12N1/21; C12N5/10; C12N15/11; C12P21/02; C12R1/91; (IPC1-7): C07K13/00; A61K37/02; C12N1/21; C12N5/10; C12N15/18; C12N15/24; C12N15/27; C12P21/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)