Title:
【発明の名称】置換されたノルボルニルアミノ誘導体、その製造方法、その医薬または診断剤としての使用およびそれらを含む医薬
Document Type and Number:
Japanese Patent JP2003517033
Kind Code:
A
Abstract:
The application discloses substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics and a medicament comprising themSubstituted norbornylamino derivatives having exo-configured nitrogen and an endo-fused five-membered ring of the formula I, or having exo-configured nitrogen and an exo-fused five-membered ring of the formula I ain which R1, R2, R3, R4, R5, A, B, S1, and S2 are as defined in the claims, are highly suitable for use as antihypertensive agents, for reducing or preventing ischemically induced damage, for use as medicaments for surgical interventions for the treatment of ischemias of the nervous system, of stroke and cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxatives, as agents against ectoparasites, for the prevention of the formation of biliary calculus, as antiatherosclerotics, as agents against late diabetic complications, carcinomatous disorders, fibrotic disorders, endothelial dysfunction, and organ hypertrophies and hyperplasias.They are inhibitors of the cellular sodium/proton antiporter. They have an influence on serum lipoproteins and can therefore be used for the prophylaxis and regression of atherosclerotic changes.
Inventors:
Uwe Heinert
Hans-Jochen Lang
Heinz-Werner Klemann
Jan-Robert Schwark
Klaus Wild
Hans-Villi Janssen
Hans-Jochen Lang
Heinz-Werner Klemann
Jan-Robert Schwark
Klaus Wild
Hans-Villi Janssen
Application Number:
JP2001545253A
Publication Date:
May 20, 2003
Filing Date:
December 01, 2000
Export Citation:
Assignee:
Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/135; A61K31/14; A61K31/155; A61K31/166; A61K31/18; A61K31/24; A61K31/277; A61K31/36; A61K31/713; A61P1/00; A61P1/10; A61P1/16; A61P3/00; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P25/00; A61P25/28; A61P33/00; A61P37/06; C07C209/08; C07C209/28; C07C211/38; C07C211/49; C07C215/28; C07C215/30; C07C217/58; C07C217/60; C07C217/62; C07C227/18; C07C229/38; C07C237/30; C07C253/30; C07D317/58; C07C255/58; C07C257/18; C07C311/37; C07C317/32; C07C323/32; (IPC1-7): C07C211/38; A61K31/135; A61K31/14; A61K31/155; A61K31/166; A61K31/18; A61K31/24; A61K31/277; A61K31/36; A61P1/00; A61P1/10; A61P1/16; A61P3/00; A61P3/06; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P25/00; A61P25/28; A61P33/00; A61P37/06; C07C209/08; C07C209/28; C07C215/28; C07C217/58; C07C227/18; C07C229/38; C07C237/30; C07C253/30; C07C255/58; C07C257/18; C07C311/37; C07C317/32; C07C323/32; C07D317/58
Domestic Patent References:
| JPH10109970A | 1998-04-28 | |||
| JPH08311012A | 1996-11-26 | |||
| JPH05339228A | 1993-12-21 | |||
| JPH10109970A | 1998-04-28 | |||
| JPH08311012A | 1996-11-26 | |||
| JPH05339228A | 1993-12-21 |
Other References:
JPN6010040213, Ｆａｒｍａｃｏ， Ｅｄｉｚｉｏｎｅ Ｓｃｉｅｎｔｉｆｉｃａ, 1979, ３４（１１）, ｐ．９４５−９５１
Attorney, Agent or Firm:
Chika Takagi (2 outside)