【発明の名称】置換されたフエニルアセチレン、これを含有する薬剤、この化合物及び薬剤を製造する方法 - Grunenthal Gesellschaft Mito Beschlenktel Haftung

Title:

【発明の名称】置換されたフエニルアセチレン、これを含有する薬剤、この化合物及び薬剤を製造する方法

Document Type and Number:

Japanese Patent JP3140494

Kind Code:

B2

Abstract:

The substituted phenylacetylenes according to the invention are specifically acting 5-lipoxygenase inhibitors and can be used, in particular, in pharmaceutical preparations for the therapy of pathologic conditions in which leukotrienes are involved as mediators. The phenylacetylenes have the general formula in which one of the radicals R1 is a hydrogen atom and the other is the group of the formula in which R3 denotes a hydrogen atom, a methyl or ethyl radical, and R4 denotes a methyl radical or an amino group, and in which R2 is a monocyclic or dicyclic aromatic or a sulphur-, nitrogen- or oxygen-containing heterocyclic radical which is optionally substituted as defined above. These compounds can be prepared according to the invention for example by reacting a compound of the formula in which R2 has the same meaning as above and one of the radicals R7 is hydrogen and the other one is the group of the formula -CO-R3, with hydroxylamine to give the oxime, reducing the latter to the correspondingly substituted hydroxylamine compound and finally introducing the group of the formula -COR4. This preparation method and others are described.

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Inventors:

Oswart Zimmer
Werner Voorenberg
Ulrich Zaip
Werner Engelberger
Michyaer Howlant
Brigitte Johanna Bossman
Johannes Schneider

Application Number:

JP18644491A

Publication Date:

March 05, 2001

Filing Date:

July 25, 1991

Export Citation:

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Assignee:

Grunenthal Gesellschaft Mito Beschlenktel Haftung

International Classes:

A61K31/15; A61K31/16; A61K31/17; A61K31/165; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/47; A61P7/02; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P29/00; A61P37/08; A61P43/00; C07C259/06; C07C275/64; C07C323/47; C07D211/28; C07D213/42; C07D215/12; C07D317/58; C07D333/20; C07D333/28; C07D333/58; C07D333/66; (IPC1-7): C07D317/58; A61K31/36; A61P11/06

Domestic Patent References:

JP4504261A

Attorney, Agent or Firm:

Mitsufumi Esaki (2 others)

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