【発明の名称】置換クロマンおよび関連化合物

Japanese Patent JPH0629248

B2

(A) Bicyclic cpds. of formula (I) and their salts are new; where n = 0 or 1; m = 0-3; X = CH2, O, S, SO, SO2, NH or 1-4C alkylimino; X1 = CH2, O, S, SO or SO2; Y+Y1 = O, or Y = H and Y1 = OH or in-vivo hydrolysable acyloxy; Z = CH2, CHMe, CH2CH2 or CH2CH2CH2; Z1 = CH or N; R = 2-, 3- or 4-pyridyl, 2-, 3-, 4- or 8-quinolyl, 1-, 3- or 4-isoquinolyl, etc , , all opt. mono- or disubstd. R1 = a C-bonded phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, pyridazinyl, cinnolinyl, phthalazinyl, pyrimidinyl, naphthyridinyl, pyrrolyl, N-R11-pyrrolyl,, indolyl, N-R11-indolyl, isoindolyl, N-R11-isoindolyl, indolizinyl, pyrazolyl, 1-R11-pyrazolyl, indazolyl, 1-R11-1H-indazolyl, 2-R11-2H-indazolyl, imidazolyl, 1-R11-imidazolyl, benzimidazolyl, 1-R11-benzimidazolyl, furyl, benzofuranyl, isobenzofuranyl, oxazolyl, benzoxazolyl, isoxazolyl, benzo(c)isoxazolyl, benzo(d)isoxazolyl, thienyl, benzothiophenyl, isobenzothienyl, thiazolyl, benzothiazolyl, isothiazolyl, benzo(c)isothiazolyl or benzo(d)isothiazolyl gp., or may be 1-pyrrolyl, 1-indolyl, 2-isoindolyl, 1-pyrazolyl, 1(1H)-indozolyl, 2(2H)-indazolyl, 1-imidazolyl or 1-benzimidazolyl when X1 = CH2 or m is at least 2, where R1 is opt. mono- or disubstd. R1 and R11 = 1-4C alkyl. (B) Intermediates of formula (II) and (III) are also new: where Y2 + Y3 = O, or Y2=H and Y3 = OH; Ra = OH or benzyloxy; Rb+Rc = hydroxymethylene or diazo, or Rb = H and Rc = Br; Rb = phenyl or R.

JEIMUZU FUREDERITSUKU ETSUGURAA
ANSONII MAAFUATSUTO
ROORENSU SHAAMAN MERUBIN JUNIA

JP26265888A

April 20, 1994

October 18, 1988

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PFIZER

A61K31/00; A61K31/045; A61K31/085; A61K31/35; A61K31/352; A61K31/353; A61K31/38; A61K31/382; A61K31/40; A61K31/425; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/47; A61K31/50; A61P3/00; A61P9/08; A61P9/10; A61P11/00; A61P11/06; C07C49/83; A61P19/02; A61P29/00; C07C43/253; C07C45/00; C07C45/62; C07C45/63; C07C45/67; C07C45/68; C07C45/71; C07C45/74; C07C49/747; C07C49/755; C07C67/00; C07D213/28; C07D213/30; C07D215/14; C07D215/20; C07D215/22; C07D215/233; C07D215/36; C07D215/38; C07D277/64; C07D311/22; C07D313/08; C07D313/12; C07D335/02; C07D335/06; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D405/04; C07D405/06; C07D405/12; C07D405/14; C07D407/04; C07D407/06; C07D409/12; C07D417/06; C07D417/12; C07D417/14; C07D419/12; C07D515/04; C12N9/99; (IPC1-7): C07D215/22; C07D215/36; C07D311/22; C07D313/12; C07D335/06; C07D401/06; C07D403/06; C07D405/06; C07D405/12; C07D405/14; C07D409/12; C07D417/12; C07D417/14

JP543047A
JP4982653A
JP51110573A
JP6016983A

【文献】米国特許4661596(US,A)

Yoshio Kawaguchi (2 outside)

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