Title:
【発明の名称】置換フェニル化合物
Document Type and Number:
Japanese Patent JPH09505043
Kind Code:
A
Abstract:
Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q(CO2R6 or OH), -CN, -C(R7)=NOR8, NO2, -O(lower alkyl)R9, -C=C-R10, -CR11=C(R12)(R13), -C(=O)CH2C(=O)CO2H, -CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, thiocarbamoyl, substituted carbamoyl, substituted thiocarbamoyl, sulphamoyl or an optionally substituted nitrogen-containing ring, m, n, o and p are independently zero or 1 and R2, R3, R4 and R5 are various groups; and physiologically acceptable salts, N-oxides and prodrugs thereof. The compounds have endothelin antagonist activity and are useful as pharmaceuticals.
Inventors:
Astors, Peter Chyars
Harper, Mark Francis
Neil Victor Harris
McCray, Ian McFarlane
Roussier, Jiyoung Achison
Lewis, Richard Allan
Smith, Christopher
Barry, Porter
Matsuka See, Clive
Harper, Mark Francis
Neil Victor Harris
McCray, Ian McFarlane
Roussier, Jiyoung Achison
Lewis, Richard Allan
Smith, Christopher
Barry, Porter
Matsuka See, Clive
Application Number:
JP51370495A
Publication Date:
May 20, 1997
Filing Date:
November 14, 1994
Export Citation:
Assignee:
Loan-Poulin Lore Limited
International Classes:
A61K31/085; A61K31/11; A61K31/165; A61K31/19; A61K31/195; A61K31/215; A61K31/27; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/42; A61K31/4245; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/66; A61P1/00; A61P3/00; A61P9/00; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P43/00; C07C43/20; C07C43/23; C07C45/00; C07C45/60; C07C45/63; C07C45/67; C07C45/71; C07C47/52; C07C47/565; C07C47/575; C07C49/76; C07C49/813; C07C49/84; C07C59/68; C07C59/88; C07C59/90; C07C65/21; C07C65/24; C07C65/26; C07C65/28; C07C69/736; C07C69/738; C07C205/34; C07C205/37; C07C205/38; C07C205/59; C07C217/76; C07C229/44; C07C233/60; C07C233/87; C07C235/06; C07C235/20; C07C235/60; C07C251/48; C07C255/41; C07C255/49; C07C255/54; C07C257/06; C07C311/29; C07C317/22; C07C323/20; C07C323/62; C07C327/48; C07D209/12; C07D213/30; C07D213/50; C07D213/55; C07D213/89; C07D231/14; C07D239/26; C07D257/04; C07D261/10; C07D261/18; C07D271/06; C07D275/02; C07D307/42; C07D317/54; C07D327/06; C07D333/16; C07D333/32; C07D333/38; C07D401/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D521/00; C07F9/40; (IPC1-7): C07C43/20; C07F9/40; C07D413/12; C07D409/14; C07D409/12; C07D405/12; C07D401/12; C07D333/38; C07D333/32; C07D275/02; C07D271/06; C07D261/10; C07D257/04; C07D239/26; C07D213/55; C07D209/12; C07C327/48; C07C323/20; C07C317/22; C07C311/29; C07C255/49; C07C235/06; C07C233/87; C07C229/44; C07C205/59; C07C65/24; C07C65/21; C07C59/88; C07C59/68; C07C49/76; C07C47/52; A61K31/66; A61K31/44; A61K31/42; A61K31/415; A61K31/40; A61K31/38; A61K31/27; A61K31/215; A61K31/195; A61K31/19; A61K31/165; A61K31/11; A61K31/085
Attorney, Agent or Firm:
Heiyoshi Odashima