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Title:
【発明の名称】二官能性キレート剤としての置換チオ尿素
Document Type and Number:
Japanese Patent JPH08502240
Kind Code:
A
Abstract:
PCT No. PCT/US93/03208 Sec. 371 Date Jun. 27, 1994 Sec. 102(e) Date Jun. 27, 1994 PCT Filed Apr. 8, 1993 PCT Pub. No. WO93/21151 PCT Pub. Date Oct. 28, 1993This invention relates to chelating agents useful for coupling metal ions to biologically active molecules. In particular, substantial thioureas for chelating metals such as technetium are provided that can be conjugated to a targeting molecule such as an antibody, a peptide or a protein.

Inventors:
Kagulin, Daniel J.
Berinka, Jr., Benjamin A.
Application Number:
JP51842393A
Publication Date:
March 12, 1996
Filing Date:
April 08, 1993
Export Citation:
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Assignee:
Cytogen Corporation
International Classes:
A61K39/44; A61K47/48; A61K51/00; A61K51/08; A61K51/10; C07C335/06; C07C335/14; C07C335/16; C07C335/22; G01N33/58; C07C337/06; C07D207/452; C07D213/34; C07D213/71; C09K3/00; C07D207/44; (IPC1-7): C07C335/06; A61K51/00; C07C335/14; C07C335/16; C07D207/452; C07D213/34; C09K3/00
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)