Title:
【発明の名称】スルホンアミド誘導体
Document Type and Number:
Japanese Patent JP2881688
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new sulfonamide derivative expressed by a specific formula and having an in inhibiting action on an elastase, high in safety and useful for treatment and prevention of chronic embolic pulmonary diseases, etc., such as pulmonary emphysema. SOLUTION: The objective compound is expressed by formula I(R<1> is a 1-8C alkyl, alkoxy, OH or a keto, etc.; (n) is 0 or an integer of 1-5; R<2> and R<3> are each H or a 1-4C alkyl, alkoxy or a halogen, etc.; R<4> is a 1-4C alkyl or alkoxy, etc.; (m) is 0 or an integer of 1-4; R<5> and R<6> are each H, OH, a 1-8C alkyl, alkoxy or a phenyl 1-4C alkoxy, etc.), concretely, 4-(2S-(t)- butyloxycarbonylpyrrolidin-1-y1 sulfonyl)-2-methylphenyl 2RS-(4-(pyrrolidin-1-y1) phenyl) butanoic ester, etc. The compound is obtained by e.g. subjecting a compound of formula II (R<1a> is a 1-8C alkyl or alkoxyl, etc.) and a compound of formula III[formula IV is formula V (R<5a> and R<6a> are each H, OH or (t)- butoxycarbonyl, etc.)] to an esterification reaction.
Inventors:
Takahiko Nakae
Hitoshi Kato
Kenji Fujita
River Bata Waichi
Hiroyuki Ohno
Hitoshi Kato
Kenji Fujita
River Bata Waichi
Hiroyuki Ohno
Application Number:
JP27134196A
Publication Date:
April 12, 1999
Filing Date:
September 24, 1996
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
A61K31/215; A61K31/335; A61K31/357; C07D295/12; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/4184; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/428; A61K31/44; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/495; A61K31/496; A61K31/535; A61K31/5355; A61K31/5375; A61K31/5377; A61K31/538; A61K31/55; A61K31/70; A61K38/55; A61P1/02; A61P1/04; A61P9/08; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P29/00; A61P43/00; C07C311/29; C07D207/16; C07D207/34; C07D209/42; C07D213/64; C07D233/64; C07D235/08; C07D235/30; C07D241/04; C07D263/26; C07D265/36; C07D277/20; C07D277/28; C07D277/30; C07D277/34; C07D277/42; C07D277/76; C07D295/14; C07D295/22; C07D317/54; C07D319/20; C07D333/24; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D453/06; C07D487/08; C07H11/00; C07K5/02; (IPC1-7): A61K31/535; A61K31/535; C07D295/14
Domestic Patent References:
| JP4283576A | ||||
| JP4226939A | ||||
| JP5194366A | ||||
| JP320253A | ||||
| JP6179645A | ||||
| JP62111963A | ||||
| JP63165357A | ||||
| JP7173062A | ||||
| JP694450B2 | ||||
| JP764801B2 | ||||
| JP7502505A |
Other References:
Ａｎｎｕａｌ Ｒｅｐｏｒｔｓ ｉｎ Ｍｅｄｉｃａｌ Ｃｈｅｍｉｓｔｒｙ（１９９４），Ｖｏｌ．２９，ｐａｇｅｓ１９５−２０４
Ｔｒｅｎｄｓ ｉｎ Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅ（１９８７），Ｖｏｌ．８，ｐａｇｅｓ３０３−３０７
Ｔｒｅｎｄｓ ｉｎ Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅ（１９８７），Ｖｏｌ．８，ｐａｇｅｓ３０３−３０７
Attorney, Agent or Firm:
Kunihisa Oya