Title:
【発明の名称】1,4,7-トリアザシクロノナン誘導体の合成
Document Type and Number:
Japanese Patent JP2788550
Kind Code:
B2
Abstract:
An improved process is described for obtaining triazacyclononanes, esepcially 1,4,7-trimethyl-1,4,7-triazacyclononame. The first step involves reacting diethylenetriamine (DET) with a sulfonylation agent to form a sulfonamidated DET, in an aqueous medium with an inorganic base. In a second step, but preferably within the same reactor vessel without isolating intermediates, the sulfonamidated DET aqueous mixture is contacted with an aprotic organic solvent in the presence of a cyclizing unit such as ethylene glycol ditosylate or ethylene dibromide, thereby resulting in a cyclized sulfonamidated triamine compound. Thereafter the protecting groups are removed and the amine is alkylated, preferably within a single reaction vessel without isolation of intermediates.
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Inventors:
MADEISON SUTEIIBUN ARAN
BATARU DEIBITSUDO JON
BATARU DEIBITSUDO JON
Application Number:
JP50201694A
Publication Date:
August 20, 1998
Filing Date:
June 16, 1993
Export Citation:
Assignee:
YUNIRIIBAA NV
International Classes:
C07D255/02; (IPC1-7): C07D255/02
Domestic Patent References:
| JPS6330479A |
Other References:
【文献】Tetrahedron,Vol.41(No.10)P.1959~1964(1985)
【文献】Khim.Geterotsikl.Soedin,1990,No.3,P401~404
【文献】Khim.Geterotsikl.Soedin,1990,No.3,P401~404
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)