Title:
【発明の名称】治療用組成物及びその製造方法
Document Type and Number:
Japanese Patent JPH05508156
Kind Code:
A
Abstract:
PCT No. PCT/SE91/00475 Sec. 371 Date Feb. 24, 1993 Sec. 102(e) Date Feb. 24, 1993 PCT Filed Jul. 3, 1991 PCT Pub. No. WO92/00732 PCT Pub. Date Jan. 23, 1992.A colon selective pharmaceutical composition for oral delivery of one or more therapeutically active substances, comprises (i) a matrix core having the active substance or substances dispersed therein, and (ii) an outer cover layer without any active substance, said matrix core and cover layer being selectively degradable by enzymes normally occurring in the colon. A method of preparing such a colon selective pharmaceutical composition comprises the steps of mixing at least one therapeutically active substance with a matrix material to prepare a matrix core having the active substance or substances dispersed therein, and coating said matrix core with a material without any active substance therein to provide the matrix core with a drug-free protective cover layer, said matrix and cover layer materials being based upon at least one substance which is selectively degradable by enzymes in the colon.
Inventors:
Edman, Peter
Chris Tensen, Arne
Weideholth, Bengt
Chris Tensen, Arne
Weideholth, Bengt
Application Number:
JP51239891A
Publication Date:
November 18, 1993
Filing Date:
July 03, 1991
Export Citation:
Assignee:
Mold, Pharmacia, Actiebo Lagu
International Classes:
A61K9/16; A61K9/22; A61K9/50; A61K47/36; (IPC1-7): A61K9/22; A61K47/36
Attorney, Agent or Firm:
Chika Takagi (2 outside)