Title:
【発明の名称】ヘルペスウイルスのチオ尿素インヒビター
Document Type and Number:
Japanese Patent JP2002531545
Kind Code:
A
Abstract:
Compounds of formula (I), wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; provided that at least one of R9-12 is not hydrogen; W is O, NR6, or is absent; Y is -(CO)- or -(CO2)-, or is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -CO2R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6, in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpes virus.
Inventors:
Bloom, Jonathan David
Karan, Kevin J. Joseph
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
Norton, Emily Boucher
Ross, Adma Antonia
O'Hara, Brian Mark
Karan, Kevin J. Joseph
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
Norton, Emily Boucher
Ross, Adma Antonia
O'Hara, Brian Mark
Application Number:
JP2000586686A
Publication Date:
September 24, 2002
Filing Date:
December 06, 1999
Export Citation:
Assignee:
Wyeth
International Classes:
A61K31/17; A61K31/343; A61K31/472; A61P31/22; C07C275/42; C07C335/18; C07C335/20; C07C335/22; C07D217/26; C07D295/088; C07D307/81; C07D307/85; (IPC1-7): C07C335/20; A61K31/17; A61K31/343; A61K31/472; A61P31/22; C07C335/18; C07C335/22; C07D217/26; C07D307/81; C07D307/85
Attorney, Agent or Firm:
Heiyoshi Odashima