Title:
【発明の名称】ヘルペスウイルスのチオ尿素インヒビター
Document Type and Number:
Japanese Patent JP2002531557
Kind Code:
A
Abstract:
Compounds of formula (I) wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
Inventors:
Bloom, Jonathan David
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
O'Hara, Brian Mark
Day Grande, Martin Joseph
Dassin, Russell Giyogi
Lang, Stanley Albert
O'Hara, Brian Mark
Application Number:
JP2000586715A
Publication Date:
September 24, 2002
Filing Date:
December 06, 1999
Export Citation:
Assignee:
Wyeth
International Classes:
A61K31/06; A61K31/075; A61K31/085; A61K31/10; A61K31/11; A61K31/136; A61K31/15; A61K31/165; A61K31/167; A61K31/17; A61K31/175; A61K31/18; A61K31/196; A61K31/215; A61K31/216; A61K31/222; A61K31/27; A61K31/275; A61K31/341; A61K31/40; A61K31/42; A61K31/426; A61K31/433; A61K31/4439; A61K31/4453; A61K31/4458; A61K31/54; A61K31/695; A61P31/12; A61P31/22; C07C335/20; C07D207/12; C07D207/14; C07D207/335; C07D209/14; C07D211/22; C07D213/40; C07D213/75; C07D215/12; C07D295/14; C07D217/12; C07D231/12; C07D231/56; C07D233/44; C07D261/08; C07D277/24; C07D277/28; C07D285/06; C07D307/52; C07D307/54; C07D333/20; C07D405/12; C07D417/12; C07D207/32; (IPC1-7): C07D207/12; A61K31/06; A61K31/075; A61K31/085; A61K31/10; A61K31/11; A61K31/136; A61K31/15; A61K31/165; A61K31/167; A61K31/17; A61K31/175; A61K31/18; A61K31/196; A61K31/215; A61K31/216; A61K31/222; A61K31/27; A61K31/275; A61K31/341; A61K31/40; A61K31/42; A61K31/426; A61K31/433; A61K31/4439; A61K31/4453; A61K31/4458; A61K31/54; A61K31/695; A61P31/22; C07C335/20; C07D207/14; C07D211/22; C07D261/08; C07D277/24; C07D285/06; C07D295/14; C07D307/54; C07D417/12
Attorney, Agent or Firm:
Heiyoshi Odashima