Title:
【発明の名称】組織プラスミノーゲン活性化因子類似体
Document Type and Number:
Japanese Patent JPH03505967
Kind Code:
A
Abstract:
A tissue plasminogen activator (t-PA) analogue in substantially inactivated one-chain form capable of being converted to the active two-chain form is modified in the region from position 414 to position 433. In particular, the t-PA analogue is one in which a positively charged amino acid residue in position 419 and optionally also in position 420 has been replaced by a negatively charged or uncharged amino acid residue to inhibit interaction with the amino acid residue in position 480.
Inventors:
Petersen, Lars Christian
Boel, Espel
Boel, Espel
Application Number:
JP50771889A
Publication Date:
December 26, 1991
Filing Date:
July 07, 1989
Export Citation:
Assignee:
NOVO NORDISK AKTIE SELSXAB
International Classes:
C12N15/09; A61K38/46; A61P7/02; C07K14/00; C12N5/10; C12N9/64; C12N9/72; C12N15/58; A61K38/00; (IPC1-7): A61K37/54; C07K13/00; C12N5/10; C12N9/64; C12N15/58; C12N15/85
Attorney, Agent or Firm:
Aoki Akira (3 outside)