Title:
【発明の名称】上皮膜タンパク質―1
Document Type and Number:
Japanese Patent JP2000507085
Kind Code:
A
Abstract:
Epithelial membrane protein-1 (EMP-1) was identified as having a high degree of homology with peripheral myelin protein 22 (PMP22) and was expressed predominantly in the digestive tract and the nervous system. EMP-1 and PMP22 define a novel family of transmembrane proteins which are involved in the regulation of cell growth and/or differentiation. Included in the invention are EMP-1 nucleic acids, and expression vectors and host cells for the recombinant production of EMP-1. Nucleic acids are used to detect EMP-1 mutation in biological samples and to treat EMP-1 related conditions by anti-sense or gene therapy. Host cells displaying EMP-1 are used to screen for EMP-1 ligands and for receptor agonists and antagonists.
Inventors:
Tyler, Fuerdon
Welshire, Andrew A
Zooter, Uri
Welshire, Andrew A
Zooter, Uri
Application Number:
JP51995697A
Publication Date:
June 13, 2000
Filing Date:
November 22, 1996
Export Citation:
Assignee:
Amjien Incorporated
A-T-Her-Jurich
A-T-Her-Jurich
International Classes:
A61K45/00; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; C12N15/02; A61K48/00; (IPC1-7): C12N15/09; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08; C12Q1/68; G01N33/15; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)
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