Title:
【発明の名称】トリーアザ大員環およびその製造方法
Document Type and Number:
Japanese Patent JPH04501569
Kind Code:
A
Abstract:
Tri-aza macrocycles of formula (1): wherein m and n, which may be the same of different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R<1>, R<2> and R<3>, which may be the same of different, is each a hydrogen atom or a group -CO2H or -P(O)(XH)R<4> (where R is an oxygen or sulphur atom and R<4> is a hydrogen atom or an alkyl or alkoxy group), with the proviso that at least one of R<1>, R<2> and R<3> is a -P(O)(XH)R<4> group; L is a covalent bond or a linker group; Z is a hydrogen atom or a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful as imaging agents, and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules, such as proteins, for use in diagnosis and therapy.
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Inventors:
Hoodie, david
Eaton, Mikle, Anthony, William
Eaton, Mikle, Anthony, William
Application Number:
JP50942090A
Publication Date:
March 19, 1992
Filing Date:
June 25, 1990
Export Citation:
Assignee:
Celtec Limited
International Classes:
A61K39/395; A61P35/00; C07D255/02; C07F9/6515; A61K51/00; (IPC1-7): A61K39/395; A61K43/00; A61K49/02; C07F9/6515
Attorney, Agent or Firm:
Akira Asamura (3 outside)