Title:
【発明の名称】腫瘍壊死因子関連ポリペプチド
Document Type and Number:
Japanese Patent JP2000515727
Kind Code:
A
Abstract:
A novel member of the tumor necrosis factor (TNF) family was identified and observed to be involved in inflammation and necrosis, especially of the liver, myelopoiesis and bone resorption. The polypeptide is termed AGP-1. Nucleic acid sequences, vectors and host cells for the expression of AGP-1 are disclosed. Methods for identifying antagonists of AGP-1, pharmaceutical compositions comprising AGP-1 and methods of treatment using AGP-1 and AGP-1 antagonists are also disclosed.
Inventors:
Marie Jayson
Simonet, William S
Dani Lenko, Damien Lee M
Simonet, William S
Dani Lenko, Damien Lee M
Application Number:
JP50089298A
Publication Date:
November 28, 2000
Filing Date:
June 06, 1997
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
A01K67/027; A61K38/00; A61K45/00; A61P7/00; A61P19/00; A61P29/00; C07K14/525; C07K14/705; C07K16/24; C12N1/21; C12N15/09; C12N15/19; C12N15/85; C12P21/08; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/577; A61K48/00; (IPC1-7): C12N15/09; A01K67/027; A61K38/00; A61K45/00; A61P7/00; A61P19/00; A61P29/00; C07K14/525; C07K16/24; C12N1/21; C12P21/08; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G01N33/577
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)