Title:
【発明の名称】がん抑制ペプチド
Document Type and Number:
Japanese Patent JPH10509147
Kind Code:
A
Abstract:
The sea hare Dolabella auricularia has yielded many structurally distinct peptides which possess antineoplastic activity. Presently the compound denominated "dolastatin 10" represents the most important of such peptides because of its demonstrated potential as an anticancer drug. The present invention relates to the systematic creation of seven unique pentapeptides by selectively coupling a tripeptide-trifluoroacetate salt with a preselected dipeptide trifluoroacetate salt which provide active molecules capable of emulating the measured therapeutic effect of dolastatin 10.
Inventors:
George Earl Pettit
Jaram Case Sri Langham
Jaram Case Sri Langham
Application Number:
JP51614896A
Publication Date:
September 08, 1998
Filing Date:
November 06, 1995
Export Citation:
Assignee:
Arizona Board of Reminds
International Classes:
A61K38/00; A61P35/02; C07D207/08; C07K5/02; C07K5/027; C07K5/03; C07K7/02; (IPC1-7): C07K5/03; A61K38/00
Attorney, Agent or Firm:
Nao Kuwahara