Title:
【発明の名称】免疫抑制のためのUV―誘発因子
Document Type and Number:
Japanese Patent JPH04504574
Kind Code:
A
Abstract:
The present invention comprises the method of selectively suppressing an immune response of a mammal to a particular alloantigen. The method includes several steps. One step is administering to a mammal an effective amount of UVB-radiation. Epidermal cell cultures, when subjected to UVA or UVB irradiation produce specific immunosuppressive factors. This UV-radiation is preferably UVA radiation (320 nm to 400 nm), or UVB-radiation (280 nm to 320 nm). It is demonstrated herein that UVA radiation results in in vitro cells producing a factor which selectively suppresses the CHS response in mammals, while UVB radiation selectively suppresses the DTH response in mammals. Another step of the inventive method involves desensitizing a mammal to a particular alloantigen. It has been determined that a mammal will become tolerant to a particular alloantigen once the subject mammal has been irradiated with a predetermined wavelength of UVR and thereafter sensitized with the particular alloantigen. This may analogously be accomplished using factors from in vitro epidermal cell cultures.
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Inventors:
Ulrich, Stephen E.
Application Number:
JP50510490A
Publication Date:
August 13, 1992
Filing Date:
March 14, 1990
Export Citation:
Assignee:
Board of Regents, The University of Texas System
International Classes:
A61K39/00; A61K41/00; A61P37/06; A61K38/00; C07K1/22; C07K14/435; C07K14/54; A61N5/06; (IPC1-7): A61K37/02; A61K39/00; A61K41/00; C07K15/06
Attorney, Agent or Firm:
Akira Asamura (3 outside)