Title:
【発明の名称】5-HT拮抗剤としての尿素誘導体
Document Type and Number:
Japanese Patent JPH11506468
Kind Code:
A
Abstract:
A compound of formula (I) wherein R<1> is cyano, thiocarbamoyl, a group of formula (a) in which R<4> is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindolyl, A<1> is lower alkylene, and m and n are each 0 or 1, a group of the formula -A<2>-R<5> in which R<5> is morpholino, piperidino, 4-arylpiperazin-1-yl, phthalimido, 1,2,3,4-tetrahydroquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl or imidazol-1-yl, and A<2> is lower alkylene, or a group of formula (b) in which R<6> and R<7> are each hydrogen, optionally substituted aryl, acyl, pyridyl(lower)alkyl, thienyl(lower)alkyl, 3,4-dihydroisoquinolinyl, (lower alkylimino) (optionally substituted aryl) methyl or lower alkyl which may have optionally substituted aryl, and A<3> is lower alkylene, and R<2> is hydrogen; or R<1> and R<2> are linked together to form (1), (2), or (3), in which R<8> is amino or acylamino, and R<9> is hydrogen, acyl or lower alkyl which may have optionally substituted aryl, and R<3> is 1-lower alkylindolyl, benzofuranyl, dihydrobenzofuranyl, or optionally substituted aryl, and a pharmaceutically acceptable salt thereof, which is useful as a medicament for prophylactic and therapeutic treatment of 5-HT mediated diseases.
Inventors:
Kiyotaka Ito
Glen w Spears
Toshio Yamanaka
Keiko Harada
Yuka Hotta
Kato Masayuki
Glen w Spears
Toshio Yamanaka
Keiko Harada
Yuka Hotta
Kato Masayuki
Application Number:
JP50030297A
Publication Date:
June 08, 1999
Filing Date:
June 04, 1996
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
International Classes:
A61K31/135; A61K31/17; A61K31/215; A61K31/27; A61K31/275; A61K31/34; A61K31/343; A61K31/40; A61K31/403; A61K31/4035; A61K31/404; A61K31/415; A61K31/4427; A61K31/443; A61K31/445; A61K31/47; A61K31/495; A61K31/535; A61P25/00; A61P39/02; A61P43/00; C07C273/00; C07C273/18; C07C275/40; C07C275/42; C07C327/48; C07C327/58; C07D209/08; C07D209/48; C07D307/79; C07D401/12; C07D403/12; C07D405/12; C07D521/00; (IPC1-7): C07C275/40; A61K31/135; A61K31/17; A61K31/215; A61K31/27; A61K31/275; A61K31/34; A61K31/40; A61K31/415; A61K31/445; A61K31/47; A61K31/495; A61K31/535; C07C273/00; C07C273/18; C07C327/48; C07C327/58; C07D209/08; C07D209/48; C07D307/79; C07D401/12; C07D403/12; C07D405/12
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