Title:
【発明の名称】糖代謝異常の治療のためのクレアチン類似体の利用
Document Type and Number:
Japanese Patent JPH11513671
Kind Code:
A
Abstract:
The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.
Inventors:
Caddler-Da Oak Lima
Teacher Beverly A.
Teacher Beverly A.
Application Number:
JP51525297A
Publication Date:
November 24, 1999
Filing Date:
October 11, 1996
Export Citation:
Assignee:
Avicena Group, Inc.
Dana-Farber Cancer Institute
Dana-Farber Cancer Institute
International Classes:
A61K31/00; A61K31/195; A61K31/197; A61K31/198; A61K31/395; A61K31/397; A61K31/40; A61K31/401; A61K31/415; A61K38/28; A61K31/4168; A61K31/4172; A61K31/495; A61K31/64; A61K31/675; A61K31/685; A61P3/00; A61P3/10; G06G7/48; G06G7/58; (IPC1-7): A61K31/195; A61K31/00; A61K31/395; A61K31/40; A61K31/415; A61K31/495; A61K31/64; A61K31/685; A61K38/28
Attorney, Agent or Firm:
Yoshiki Ishida (1 person outside)