Title:
【発明の名称】ビタミンD類似体
Document Type and Number:
Japanese Patent JP2000502063
Kind Code:
A
Abstract:
PCT No. PCT/DK96/00502 Sec. 371 Date Jan. 8, 1998 Sec. 102(e) Date Jan. 8, 1998 PCT Filed Dec. 2, 1996 PCT Pub. No. WO97/20811 PCT Pub. Date Jun. 12, 1997The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R1 and R2 stand for methyl or ethyl, or, when taken together with the carbon atom bearing the group X, can form a C3-C5 carbocyclic ring; Q is either a single bond or a C1-C8 hydrocarbylene in which one of any methylene groups not directly bonded to the carbonyl group may optionally be replaced by an oxygen atom (or methyl by hydroxy); Y is either a single bond or C1-C8 hydrocarbylene; and derivatives of (I) in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
Inventors:
Culverly, Martin John
Application Number:
JP52088297A
Publication Date:
February 22, 2000
Filing Date:
December 02, 1996
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited Actiesel Scab (Lebens Chemisque Fabric Production Actiesl Scab)
International Classes:
A61K31/00; A61P3/00; A61P3/10; A61P9/00; A61P9/12; A61P11/00; A61P11/06; A61P13/00; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61K31/59; A61P25/28; A61P35/00; A61P37/00; A61P37/06; C07C401/00; (IPC1-7): C07C401/00; A61P3/10; A61P9/12; A61P11/06; A61P13/12; A61P17/06; A61P17/00; A61P17/02; A61P17/14; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P37/00; A61P37/06; A61K31/59
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)