Title:
【発明の名称】抗腫瘍剤として有用なアミノアントラセンジオン‐ビス白金錯体
Document Type and Number:
Japanese Patent JPH03503046
Kind Code:
A
Abstract:
Bis-platinum complexes of formula I wherein A is a disubstituted 1,4-anthracenedione; X, X min are ligands selected from the group consisting of Cl, Br, OH, CH3 SOCH3.OH or CH3SOCH3.Hal or, taken together, form the anion of a dicarboxylic acid; m is zero, 0.5 or an integer from 1 to 5; Solv is a solvent of crystallization; Ra is hydrogen, alkyl optionally substituted by hydroxy groups and/or interrupted by oxygen atoms; Rb is alkyl optionally substituted by hydroxy, alkoxy, polyalkoxy or sulphonic groups or a residue of an amino-sugar and n is an integer from 2 to 3. Compounds I are useful as anti-tumor agents.
Inventors:
Pasini Alessanduro
Zunino Franco
Tofanetti Odordo
Gandolfi Carmelo
Tonella Sergio
Spinelli Silvano
Zunino Franco
Tofanetti Odordo
Gandolfi Carmelo
Tonella Sergio
Spinelli Silvano
Application Number:
JP50032588A
Publication Date:
July 11, 1991
Filing Date:
December 07, 1988
Export Citation:
Assignee:
Beringer Mannheim Italy Esse Pier
International Classes:
A61K31/28; A61K31/282; A61K31/70; A61K31/7135; A61P35/00; C07F15/00; C07H23/00; (IPC1-7): A61K31/28; A61K31/70; C07F15/00; C07H23/00
Attorney, Agent or Firm:
Takano Takewaga
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