Title:
【発明の名称】アザマクロサイクルおよびその製法
Document Type and Number:
Japanese Patent JPH03504510
Kind Code:
A
Abstract:
Aza macrocycles of the formula (1) wherein A is a group -(CH2)p- or -(CH2)p N(R)(CH2)q- where R is a group -CH(R<4>)X<4>; m, n, p, and q, which may be the same or different, is each an integer 2 or 3; R<1>, R<2>, R<3> and R<4>, which may be the same or different, is each a group -CO2H, -P(R<5>)O2H (where R<5> is a hydrogen atom or an alkyl or alkoxy group), -PO3H2 or -CONR<6>R<7> (where R<6> and R<7>, which may be the same or different is each a hydrogen atom or an alkyl group); X<1>, X<2>, X<3> and X<4>, which may be the same or different, is each a hydrogen atom or an alkyl group, or a linker group, with the proviso that at least one of X<1>, X<2>, X<3> or X<4> is a linker group; and protected derivatives and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules such as proteins for use in diagnosis and therapy.
More Like This:
Inventors:
Hoodie, david
Beeley, Niger, Robert, Arnold
Millikan, Thomas, Andrew
Beeley, Niger, Robert, Arnold
Millikan, Thomas, Andrew
Application Number:
JP50474090A
Publication Date:
October 03, 1991
Filing Date:
February 12, 1990
Export Citation:
Assignee:
Celtec Limited
International Classes:
C07D403/02; A61K31/395; A61P43/00; C07D255/02; C07D257/02; C07D403/12; (IPC1-7): A61K31/395; C07D255/02; C07D257/02; C07D403/02
Attorney, Agent or Firm:
Akira Asamura (3 outside)