Title:
【発明の名称】5α-リダクターゼ阻害活性を有するベンゾイルアミノフェノキシブタン酸誘導体およびそれらを有効成分として含有する薬剤
Document Type and Number:
Japanese Patent JPH07107037
Kind Code:
B2
Abstract:
A benzoylaminophenoxybutanoic acid derivative of general formula: [wherein A represents oxygen, sulfur or sulfinyl, R<1> represents hydrogen or methyl, R<2> represents a group of the general formula: [wherein B represents oxygen, sulfur or NR sec (wherein R sec represents hydrogen or alkyl, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> represent independently, hydrogen, alkyl, halogen or trifluoromethyl, m represents 0 or 1, n is from 1 to 4, and R<9> and R<1><0> represent, independently, hydrogen, alkyl, optionally substituted phenylalkyl, optionally substituted benzoyl or tetrahydronaphthyl, with the proviso that R<9> and R<1><0> do not simultaneously represent hydrogen or non-toxic salts thereof, possess inhibitory activity on 5 alpha -reductase, which is indicative of utility in treating and/or preventing alopecia, acne or prostatic hypertrophy.
Inventors:
Nakai Hisaro
Hiroshi Terashima
Yoshinobu Arai
Hiroshi Terashima
Yoshinobu Arai
Application Number:
JP13541088A
Publication Date:
November 15, 1995
Filing Date:
June 03, 1988
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
A61K8/42; A61K8/44; A61K31/19; A61P13/02; A61P15/00; A61P17/00; A61K8/00; A61P43/00; A61Q5/00; A61Q7/00; A61Q19/00; C07C67/00; C07C231/00; C07C235/56; C07C237/40; C07C313/00; C07C317/44; C07C323/52; C12N9/99; (IPC1-7): C07C235/56; A61K7/06; A61K31/19; C07C237/40; C07C317/44; C07C323/52
Attorney, Agent or Firm:
Kunihisa Oya