Title:
【発明の名称】ビシクロ環系アミノ誘導体およびそれを含有するPGD2拮抗剤
Document Type and Number:
Japanese Patent JP3195361
Kind Code:
B2
Abstract:
A compound of the formula (I): wherein for example, a compound below: wherein R1 is CH3, H or Na; and X1-X2-X3 is or a salt or a hydrate thereof is useful as a PGD2 antagonist and can be used as a drug for treating diseases in which mast cell dysfunction is involved, for example, systemic mastocytosis and disorder of systemic mast cell activation, and also tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, injury due to ischemic reperfusion, and as an anti-inflammatory agent. It is particularly useful in the treatment of nasal occlusion.
Inventors:
Mitsuaki Ohtani
Akinori Arimura
Tatsuo Tsuri
Junji Kishino
Honma Tsunetoshi
Akinori Arimura
Tatsuo Tsuri
Junji Kishino
Honma Tsunetoshi
Application Number:
JP50372497A
Publication Date:
August 06, 2001
Filing Date:
June 19, 1996
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
A61K31/557; C07C233/52; C07C233/63; C07C233/74; C07C233/81; C07C233/84; C07C235/22; C07C235/36; C07C235/42; C07C235/54; C07C235/84; C07C237/38; C07C237/42; C07C245/08; C07C251/48; C07C251/86; C07C255/57; C07C271/24; C07C275/42; C07C281/14; C07C309/65; C07C311/13; C07C311/20; C07C311/29; C07C311/37; C07C311/43; C07C311/46; C07C311/51; C07C317/44; C07C323/62; C07C337/08; C07D207/34; C07D209/08; C07D209/10; C07D209/12; C07D209/42; C07D209/88; C07D213/56; C07D213/81; C07D215/36; C07D221/12; C07D235/06; C07D257/04; C07D261/18; C07D263/57; C07D271/06; C07D271/107; C07D275/03; C07D277/20; C07D277/56; C07D279/20; C07D279/22; C07D285/06; C07D285/12; C07D295/192; C07D307/68; C07D307/84; C07D307/91; C07D311/12; C07D311/24; C07D311/82; C07D313/14; C07D317/48; C07D319/24; C07D333/18; C07D333/24; C07D333/32; C07D333/34; C07D333/36; C07D333/38; C07D333/62; C07D333/68; C07D333/76; C07D333/78; C07D337/14; C07D521/00; C07F9/535; C07D263/56; C07D271/10; C07D275/02; (IPC1-7): A61K31/201; A61K31/231; A61K31/335; A61K31/341; A61K31/343; A61K31/352; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/403; A61K31/404; A61K31/41; A61K31/4164; A61K31/42; A61K31/423; A61K31/4245; A61K31/426; A61K31/433; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/473; A61K31/5375; A61K31/5415; A61K31/63; A61K31/655; A61K31/66; A61P11/02; A61P11/06; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07C233/52; C07C233/84; C07C271/24; C07D521/00
Domestic Patent References:
| JP2180862A | ||||
| JP63139161A | ||||
| JP6149A | ||||
| JP6452751A | ||||
| JP2218660A | ||||
| JP4211642A |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)