Title:
【発明の名称】強心作用を有する化合物類
Document Type and Number:
Japanese Patent JPH02500518
Kind Code:
A
Abstract:
Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure wherein: A is +TR and R1, R2, R3, R4, R8, R10, R11, R12, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23 and R24 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms; wherein the substituted phenyl group is substituted by one or more of lower alkyl, lower alkoxy, amino, lower alkyl amino, lower alkyl mercapto, hydroxy, hydroxy lower alkyl, acetoxy, benzyloxy, phenoxy, lower alkyl sulfinyl or lower alkyl sulfonyl; R13 is H, lower alkyl of 1-4 carbon atoms, alkoxy lower alkyl of 1-4 carbon atoms, hydroxy lower alkyl of 1-5 carbon atoms, amino, carbamoyl, cyano, lower alkyl carbamoyl of 1-4 carbon atoms, formyl, amino lower alkyl of 1-4 carbon atoms, carboxy, carbalkoxy, or tetrazolyl; R3 and R4 together may form =O; R16 and R17 together may form a carbon-carbon bond; n is 0 or 1; and O is 0 or 1.
Inventors:
Spada Alfred Pea
Campbell Henry F
Coola Dornado E
Stat William Elle
Face william sea
Molino Bruce F
Campbell Henry F
Coola Dornado E
Stat William Elle
Face william sea
Molino Bruce F
Application Number:
JP50694887A
Publication Date:
February 22, 1990
Filing Date:
October 27, 1987
Export Citation:
Assignee:
Loora International (Overseas) Incorporated
International Classes:
C07D475/02; A61K31/435; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/519; A61K31/53; A61K31/55; A61P37/04; C07D471/04; C07D475/00; C07D487/04; (IPC1-7): A61K31/435; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/53; A61K31/55; C07D471/04; C07D475/02; C07D487/04
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)