【発明の名称】アザ大環状化合物を含む結合体化合物及びその製造方法

Title:

【発明の名称】アザ大環状化合物を含む結合体化合物及びその製造方法

Document Type and Number:

Japanese Patent JPH05500970

Kind Code:

A

Abstract:

Conjugate compounds are described comprising a compound of formula (1)

wherein     A is a group -Alk<3>- or -Alk<3>N(R<4>)Alk<4>-; Alk<1>, Alk<2>, Alk<3> and Alk<4> which may be the same or different is each a C1-4alkylene chain optionally substituted by one or more C1-6alkyl groups; and R<1>, R<2>, R<3> and R<4>, which may be the same or different, is each a hydrogen atom or a group -AlkR<5> where Alk is an optionally substituted straight or branched C1-6 alkyl group and R<5> is a hydrogen atom or a -CO2H, -CONR<6>R<7> (where R<6> and R<7>, which may be the same or different is each a hydrogen atom or an alkyl group) or -P(X<1>)(X<2>R<8>)L group where X<1> and X<2> is each an oxygen or sulphur atom, R<8> is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R<1>, R<2>, R<3> and R<4> is a group AlkP(X<1>)(X<2>R<8>)L where L is a linker group; and metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.

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Inventors:

Hoodie, david
Beeley, Nigel, Robert, Arnold
Millikan, Thomas, Andrew

Application Number:

JP50752691A

Publication Date:

February 25, 1993

Filing Date:

April 18, 1991

Export Citation:

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Assignee:

Celtec Limited

International Classes:

A61K38/00; A61K39/395; A61K49/00; A61K49/06; A61P35/00; C07D257/02; C07F9/6515; A61K31/70; C07F9/6524; C07K14/00; C07K16/00; (IPC1-7): A61K31/70; A61K37/02; A61K39/395; A61K49/00; C07F9/6515; C07F9/6524; C07K15/12

Attorney, Agent or Firm:

Akira Asamura (3 outside)

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