CYCLOALKYL-AND HETEROCYCLYL-SUBSTITUTED IMIDAZOLYLPROPENOIC ACID DERIVATIVES

Japanese Patent JPH0625179

A

PURPOSE: To provide new compds. useful for treatment of hypertension, atherosclerosis, etc.

CONSTITUTION: These compds. of formula I (where R1 is a (substd.) 1-8C alkyl, alkenyl or 3-8C cycloalkyl; R2 is H, a halogen, hydroxyl, nitro, cyano, etc.; R3 is a 3-8C cycloalkyl or heterocyclyl; n is 0-4; R4 is H, a 1-8C alkyl or phenyl; R5 is a compd. of formula II (R6 is H, a halogen, cyano, nitro, etc.; R7 is carboxyl, a 1-6C alkoxycarbonyl, etc.), etc.), such as 3-[(2-n-butyl-1-{(2- etoxycarbonylfuran-5-yl)methyl}-1H-imidazole-5-yl]-2-cyclopentylmethyl-2-propenic acid methyl ester are obtained by dehydrating a compd. of formula V obtained by reacting a compd. of formula III with a compd. of formula IV (T is a 1-8C alkyl or phenyl).

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TOOMASU KUREMAA
YURUGEN DORETSUSERU
PEETAA FUAI
RUDORUFU HANKO
BARUTAA HIYUPUSHIYU
URURIHI MIYURAA
MATEIASU MIYURAA GURIIMAN
MARUTEIN BOIKU
SUTANISURAFU KATSUDA
ANDOREASU KUNORU
YOHANESUUPEETAA SHIYUTASHIYU
SHIYUTEFUAN BOORUFUAIRU

JP9493793A

February 01, 1994

March 31, 1993

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BAYER AG

A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61P9/10; A61P43/00; C07D233/54; A61K31/415; C07D233/64; C07D233/66; C07D401/06; C07D405/06; C07D409/06; C07D521/00; (IPC1-7): C07D233/64; A61K31/415; A61K31/44; C07D233/66; C07D401/06; C07D405/06; C07D409/06

Heiyoshi Odashima

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