Title:
【発明の名称】d,l↓-5↓-メチルテトラヒドロ葉酸及びその塩の製造方法
Document Type and Number:
Japanese Patent JPS5831353
Kind Code:
B2
Abstract:
Process for the preparation of d,l-5-methyltetrahydrofolic acid and its salts of the formula 1 in which X is hydrogen, an alkali metal or the equivalent of an alkaline earth metal, by reduction of folic acid with NaBH4 and methylation of the tetrahydrofolic acid obtained with aqueous solutions of formaldehyde and sodium borohydride in an inert gas atmosphere. The process is simple and can be carried out without separation of intermediates while carrying out the process steps successively in the same reaction vessel. The final products are obtained in a yield of more than 80%, relative to folic acid employed, in a purity of more than 99%. The compounds of the formula I obtained are non-toxic, stable at physiological pH and suitable for the preparation of liquid or solid pharmaceutical compositions for any type of application in human therapy. Such compositions exhibit haematopoietic action, hepatoprotective and antineoplastic action.
Inventors:
FUEDERIKO GENNARI
Application Number:
JP1863778A
Publication Date:
July 05, 1983
Filing Date:
February 22, 1978
Export Citation:
Assignee:
BIORISAACHI SA ESU DERU DOKUTORU RIBIO KAMOTSUTSUI ANDO CO
International Classes:
A61K31/519; A61K47/18; A61P7/00; C07D475/04; (IPC1-7): C07D475/04
Attorney, Agent or Firm:
Akihide Sugimura
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