4-AMINO-2-PIPERAZINYLPYRIMIDINE DERIVATIVE AND ITS PREPARATION

Title:

4-AMINO-2-PIPERAZINYLPYRIMIDINE DERIVATIVE AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS5857370

Kind Code:

A

Abstract:

NEW MATERIAL:A 4-amino-2-piperazinylpyrimidine derivative expressed by formulaI(R1 and R2 are H, lower alkyl or together joined to form alkylene; R3, R4 and R5 are H or lower alkyl; Y is nitrile or lower alkoxycarbonyl).

EXAMPLE: 2-(4-β-Carboethoxyethyl)-1-piperazinyl)-4-ethylaminopyrimidine.

USE: An intermediate for antimicrobial agents {2-(1-piperazinyl)-8-alkyl-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid and analogous compounds thereof}.

PROCESS: A piperazine derivative expressed by formula II is reacted with a 4- amino-2-halogenopyrimidine derivative expressed by formula III (X is halogen) to give the compound expressed by formulaI.

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Inventors:

ISAYAMA SHIGERU
MORIMOTO TEIJIROU
KIHARA NORIAKI
TAKAHASHI SHIGERU
ISHIDA TATSUKAZU
YAMAGATA HIKARI

Application Number:

JP15479881A

Publication Date:

April 05, 1983

Filing Date:

October 01, 1981

Export Citation:

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Assignee:

MITSUI PETROCHEMICAL IND

International Classes:

C07D471/04; C07D239/48; (IPC1-7): C07D239/48; C07D471/04

Attorney, Agent or Firm:

Shigemitsu Nakajima

Previous Patent: マツモトコナカイガラムシの性誘引物質、及び性誘引剤

Next Patent: FLUORINE-CONTAINING 2-AMINO (OR ALKYLAMINO)-2-THIAZOLINE COMPOUND AND ITS PREPARATION