Title:
【発明の名称】11-オキソゴナ-9-エンの新規な誘導体の製造法
Document Type and Number:
Japanese Patent JPS5831360
Kind Code:
B2
Abstract:
1451721 11-Oxygenated steroids ROUSSEL UCLAF 4 Jan 1974 [5 Jan 1973] 00354/74 Heading C2U The invention comprises compounds I infra, their preparation from compounds II-VII and their conversion into compounds VIII-X R = Me, Et, Pr ; R1 = C 1-3 alkyl ; R2 =oxo, ketal or (H, #-OR3 ); R3 =H or C 1-12 carboxylic acyl; R4 =ketal or (H, #-OR3 ); R5 =oxo or (H, #- OR3 ); X=H or OH; Y=C 1-4 alkyl or haloalkyl ; W=H or OCOY; Z = H or #4 -unsaturation. Reagents: II # III epoxidizing agent; III # IV Lewis acid; IV # I(X=H), e.g. alumina or alkali metal base; IV # V epoxidizing agent; V # I(X=OH) strong base; IV # VI, e.g. alkali metal alcoholate; VI # VII epoxidizing agent; VII # I(X=OH) alkaline agent; I(R2 =oxo) # I(R2 =ketal), e.g. ethylene glycol or specified dioxolanes I(R2 = R4 ) # VIII RMgHal, then functional deriv. of YCO 2 H; VIII (W=H) # IX (Z = H) acid then base; VIII (W = OCOY) # IX (Z = #4 ) acid; I(X = α-H; R2 =R4 ) # X RMgHal; X # IX (10α-R; Z=a-H) acid.
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Inventors:
DANIERU KUUSUDEIEERU
RYUSHIAN NEDORETSUKU
BESUPERUTO TORERI
RYUSHIAN NEDORETSUKU
BESUPERUTO TORERI
Application Number:
JP15081382A
Publication Date:
July 05, 1983
Filing Date:
September 01, 1982
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
C07J21/00; C07J1/00; C07J15/00; C07D; (IPC1-7): C07J21/00
Attorney, Agent or Firm:
Motohiro Kurauchi
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